Premarin is an amazing drug, which contains conjugated estrogen. It is isolated from the urine of pregnant mares and is used to get relief from menopausal symptoms.
Class of this drug: Female hormone
Available dose of this drug: 0.3, 0.625, 0.9, 1.25 and 2.5 mg
Available dosage form of this drug: Oral formulation
How Conjugated Estrogen works?
This steroidal hormone shows its action by binding to the certain receptors to stimulate specific protein synthesis that involve in the production of secondary sexual characteristics and also helpful in metabolism of fat and maintains body mass. This drug produces its effect on many tissues in the body. It also enhances the growth of inner lining of the uterus and also discharges from cervix.
What are the indications of Premarin?
It is a drug, which is used as hormone replacement therapy for enhancing the level of estrogen in the body during the period of menopause. Through this, it is helpful to provide relief from menopausal symptoms, which can cause by estrogen deficiency. It provides relief from hot flashes, sleeplessness, mood swings, premarin vaginal dryness, burning, itching and insomnia. This drug is also used by postmenopausal female, who a hysterectomy.
This medicine is also used to treat osteoporosis.
It is also effectively used to treat breast cancer in both male and female.
It is also used to rectify the problem of female hypogonadism by restoring the estrogen level.
This drug is also used to treat prostate cancer in males.
What are the contraindications of Premarin?
This should not be taken by an individual if you
• Allergic to this drug
• Recent or past history of uterus or other estrogen dependent cancer
• History of thrombophlebitis and deep vein thrombosis
• Pulmonary embolism
• Hepatic disorders
• Severe hypertension
• History of stroke and heart attack
• Abnormal genital bleeding
• Problem with breast
What are the drug interactions of Premarin?
Certain drugs that can interact with this medicine and leads to harmful effects on the health of the patients are:
• Anti epileptic drugs
• Anti tuberculosis drugs
• Thyroid replacement therapy
• St. john's wort
• Anti coagulant drugs
• Anti fungal drugs
• Oral diabetic drugs
• Vitamin C
• Tricyclic anti depressants
• Major tranquilizers
How to store Premarin?
• Temperature should not be more than 30° C
• Protect the dosage form from sunlight and moisture
• Store in cool, dry and clean place
How should you take Premarin?
Each dosage pack of this drug contains 28 tablets. This drug should be consumed by oral route, with a glass of water. One tablet should be taken in a day, for 28 days.
What to do in case you missed a dose of Premarin?
Skip the dose in case you missed any dose of this drug and take next dose on its time.
What happen in case of overdose?
Don't increase your dose for long period; as this can enhance the risk of breast cancer, stroke, endometrial cancer and deep vein thrombosis.
What are the undesired effects of this Premarin?
Various minor undesired effects of this drug are:
• Changes in weight or appetite
What are the safety measures while taking this Premarin?
Avoid taking this drug during pregnancy.
Avoid consuming grapefruit juice; as it potentially enhance the absorption of estrogen.