Vagifem is most widely used vaginal tablets used to treat vaginal infection in women that basically includes  itching, burning, and dryness in or around the vaginal area in women past menopause. Vagifem possess key pharmaceutical ingredient known as Estradiol.


Estradiol is fundamental steroids or female sex hormone responsible for the development and maintenance of female reproductive tissues, but it also has important effects in many other tissues including bone. It is found in both male and female, while estrogen levels in men are lower compared to women, estrogens have essential functions in men as well.


Estradiol has the fundamental role to support the lining of the vagina and fallopian tube, the cervical glands and the endometrial; it enhances growth of the myometrium. Estradiol maintains oocytes or ovum in the ovary and during the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation and conjunction with progesterone, prepares the endometrium for implantation. During pregnancy, estradiol increases due to placental production and has a role in the maintenance of pregnancy. Estradiol in female produces breast development, changes in the body shape, affecting bones, joints, and fat deposition


Vagifem is a vaginal estrogen tablet. Works by increasing the amount of estrogen in the body of female and produces its pharmacological action in her body; who does not produce enough on their own.


How to take Vagifem?

To take the vaginal tablets of Vagifem you should consider the following recommended guidelines-  


  • Take the Vagifem tablets by inserting into vagina, for Initial dose: One vaginal tablet daily for two weeks and for a Maintenance dose: take one vaginal tablet twice a week.
  • Place the finger of one hand on the applicator plunger. Use the other hand to gently and comfortably guide the applicator into the vagina. If the tablet falls out of the applicator before inserting the filled applicator, use a new applicator with a fresh tablet.
  • Insert the tablet into vagina until half of the applicator is in your vagina, gently press the plunger until you hear a click and the plunger is fully depressed. This will eject the tablet inside your vagina. The tablet will dissolve slowly over several hours.
  • Throw away the plunger after depressing it into there. Do not reuse the applicator.

What are the adverse reactions of Vagifem?

In randomized studies shows that Vagifem  shows some minor and insignificant side effects in the body of a lady that includes vaginal bleeding, nausea, vomiting, vulvovaginal mycotic infection, vulvovaginal pruritus, back pain, and diarrhea.


What is the important information about Vagifem?

The use of Vagifemshould not be recommended by women who exhibit one or more of the following: undiagnosed abnormal genital bleeding; breast cancer; known or suspected estrogen-dependent neoplasia; and blood related disorder. It should be used cautiously in liver impairment or disease; or in suspected pregnancy. Women should avoid some medication along with Vagifem as the combination may lead to undesired effects; the drugs are Azole antifungal like Ketoconazole, Barbiturates drugs like Phenobarbital and thyroid hormones.  Avoid grapefruit juice along with this medication as it may increase the risk of side effects of Vagifem.


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