Menopause is not a dysfunction. It is a natural metabolic change that is associated with reproductive abilities. It is a stage in life when a woman stops her normal menstrual cycle and it occurs generally in late 40 to 50 years of age. At this stage of life, the ovulation has stopped and no more production of estrogen. The symptoms associated with menopause include mood swings, joint ache, hot flashes, night sweats, insomnia and others. The severity of hot flashes may interrupt normal activities and disrupt the sleep pattern. When a women lack regular sleep for a long term then this may cause weight gain, anxiety, cardiac problem, high blood pressure and slowed metabolism.


Postmenopause is a time of women's life after menopause. In postmenopausal condition due to the result of several factors or due to the lowering of estrogen that may enhance the risk of health conditions such as osteoporosis and cardiac disease. There are some postmenopausal symptoms such as hot flashes, vaginal dryness, and vaginal atrophy that may interfere with the daily life of a woman. Hot flashes also are known as hot flush, it is a sudden feeling of heat and occasionally a red, flushed face and sweating. Vaginal dryness is a minor irritation and lack of moisture inside the vagina. Vaginal atrophy occurs due to thinning and shrinking of the vaginal tissues and leads to inflammation in the vagina and outer urinary tract. The menopause occurs due to insufficient production of estrogen and progesterone. The best possible method for the treatment of postmenopausal symptoms is hormonal replacement therapy with conjugated estrogen. Buy conjugated estrogen at the lowest economic rates.

 

The mixture of estrogen hormones is known as Conjugated estrogen used in the management of symptoms of menopause, like hot flashes, vaginal dryness, and vaginal atrophy. The other applications of conjugated estrogen are the prevention of osteoporosis in postmenopausal women, replacement of estrogen in women with ovarian failure or surgical removal of the ovary and as a part of cancer treatment in women and men.

 


What is the exact mechanism of action of Conjugated estrogen?


Conjugated estrogen acts on the hypothalamus gland in the brain and decrease the secretion of Gonadotrophin-releasing, thereby causing a reduction in the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary.

 

How to use this medicine?


Conjugated estrogen tablet is commercially available in different strengths are 0.3, 0.45, 0.625, 0.9, and 1.25 mg and dosages of this medicine are given below.

 

For osteoporosis: Take 0.3 mg of conjugated estrogen orally with a glass of water.

 

For Postmenopausal Symptoms: Take 0.3 mg of Conjugated estrogen orally as an initial dose and the maintenance dose is 0.45 to 1.25 mg of this medicine.

 

For breast cancer: Take 10 mg of conjugated estrogen orally three times a day for at least three months.

 

For ovarian failure: Take 1.25 mg of conjugated estrogen orally once a day for 3 weeks on one week off.

 

What are the side effects of conjugated estrogen?


A patient may come across some side effects like headache, stomach ache, nausea, back pain, joint ache, unusual vaginal bleeding, nervousness, rash, swelling in the hands or feet, bloating and breast tenderness or breast pain.

 

What are the precautionary steps a patient has to follow while using this medicine?

• If you have allergic reactions with conjugated estrogen then don't use this medicine.
• If you are a pregnant or a breastfeeding mother, then avoid using this medicine.
• Smoking should be prohibited while using this medicine because it may risk of heart disease or stroke.
• It is not indicated for a longer period because prolonged use of this medicine may increase the risk of heart attack, stroke, blood clots, dementia, breast cancer, or uterine cancer.
• It should not be taken with other oral contraceptive hormones such as Progestin and estrogen.

 

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