Pregnyl HCG is a pyrogen free and high purified preparation available in the form of intra-muscular injection.  This hormone is used for treatment of various conditions that are mentioned below:

  • It helps in stimulating ovulation in females under going through the fertility treatment
  • Stimulates the final maturation of eggs in females undergoing through the in-vitro fertilization treatment
  • For treating low sperm count in men
  • To treat delayed puberty in boys (a condition in which development of secondary sexual characteristics does not takes place at the age 12 - 14 years) 

Pregnyl HCG is the most used hormone by doctors for the treatment of infertility in females and for treating delayed puberty in boys. It is very effective and powerful medication and most of the people are satisfied with the results of this medication. 

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Working of Pregnyl HCG: Human chorionic gonadotropin shows its therapeutic effect by activating the production of gonadal steroid hormones by stimulating Leydig cells of testis to liberate androgens and the corpus luteum from the ovary to generate progesterone.

What is the prescribed dose of Pregnyl HCG?

For treatment of Prepubertal Cryptorchidism: 

  • Regimen 1: A dose of 4000 USP units should be injected thrice in a week for 3 weeks. 
  • Regimen 2: A dose of 5000 USP units are injected every second day for 4 injections.
  • Regimen3: A person should inject 15 injections for 500 to 1000 USP units at a period of 6 weeks.
  • Regimen 4: A dose of 500 USP units should be injected 3 times in a week for 4 to 6 weeks. 

For treatment of Hypogonadotropic Hypogonadism in males:

Regimen 1: A person should inject a dose of 500 to 1000 USP units, thrice in a week for 3 weeks, followed by the dose of 500 to 1000 USP two times in a week for 3 weeks.

Regimen 2: A dose of 4000 USP units should be injected thrice in a week for 6 to 9 months, after that the dose should be reduced to 2000 USP units thrice in a week for an additional 3 months. 

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Various circumstances in which Pregnyl HCG should not be used are: 

  • If you are hypersensitive to this hormone then you should avoid consumption of this medicine.
  • Avoid intake of this medicine in case of renal and hepatic disorder.
  • If you are suffering from uterine fibroids, heart disease and polycystic ovarian syndrome, then you should not take this medication.
  • Do not use this hormone if you are experiencing abnormally early puberty.

Adverse effects that are exhibited Pregnyl HCG are fatigue, headache, irritability, nausea, pain, swelling, bruising, redness at the injection site, restlessness, tiredness, allergic reactions like rash, hives,  itching,  difficulty breathing, tightness in the chest, swelling of the mouth, face, lips , tongue and unusual hoarseness.

Various precautionary measures to be followed while using Pregnyl HCG are:

  • Breast feeding females should not feed their child while using this medication.
  • Females who are already pregnant should avoid use of this hormone.
  • This hormone is not meant for children less than 4 years of age.
  • Before starting infertility treatment, your doctor should check the functioning of adrenal gland and thyroid gland. 

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