Cancer is the most prevailing disease worldwide that has caused about 8.2 million cancer deaths in 2012 which is to rise by about 70% by next two decades. The most frequent cancer deaths are caused by cancers of lungs, liver, stomach, colorectal, breast, and esophageal cancer. Cancer actually arises from one single cell. The change of normal cell to tumor cell is actually a multistep process, basically growth from a pre-cancerous lesion to a malignant tumor. Use of alcohol, tobacco products, unhealthy diet and physical activity are the major causes of cancer. Hepatitis B and C Virus, Human Papilloma Virus are the major factors responsible for liver cancer and cervical cancer.


Liver cancer has been at utmost rise these days. Liver cancer particularly called as hepatocellular carcinoma is particularly characterized by abdominal pain, yellow skin, nausea and liver dysfunction. There are various causes for the development of hepatocellular carcinomas such as the use of anabolic steroids, diabetes, metabolic disorders and Wilson's disease.


Generic Sorafenib is available with the brand name Nexavar which is used to cure the symptoms of liver cancer is available online at our website.


Sorafenib for liver cancer

How Sorafenib acts?

Sorafenib interacts with multiple intracellular (CRAF, BRAF, and mutant BRAF) and cell surface kinases (KIT, FLT-3, VEGFR-2, VEGFR-3, and PDGFR). Several of these kinases are thought to be involved in angiogenesis, thus, Sorafenib reduces blood flow to the tumor. Sorafenib is unique in targeting the Raf/Mek/Erk pathway. By inhibiting these kinases, genetic transcription involving cell proliferation and angiogenesis is inhibited.

How to use Sorafenib?


Sorafenib is most commonly available with the brand name NEXAVAR in the strength of 200mg tablet. These tablets need to be taken orally twice a day and particularly empty stomach. Generally, the dosage and schedule of the medication are prescribed by the doctor according to the condition of the patient. Do not crush or chew the tablet. Swallow it as a whole.


However, there are some side effects likely to interfere with Sorafenib such as rash, fatigue, diarrhea, hand-foot syndrome, high blood pressure, nausea, hair loss, low white blood cell count, dry skin, abdominal pain and weight loss.


Precautionary measures:

There are some precautionary measures to be kept in mind while using Sorafenib such as:

  • Before starting this medication, ensure to tell your doctor if you are taking any over the counter medication, herbal medicine, dietary supplement, vitamins or minerals
  • Use of Warfarin and Aspirin can cause serious side effects so avoid using this medication
  • Do not receive any sort of vaccination or immunization without consulting your physician
  •  Avoid using this medicine during pregnancy and lactation as it may be hazardous for the fetus
  • Avoid exposure to sunlight and maintain good nutrition diet
  • Do not drink alcohol beverages while using this medication
  • Avoid any sport or activity that causes injury

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